发明名称 |
DNA Methylation Changes Associated with Major Psychosis |
摘要 |
The present invention provides a method of identifying one or more epigenetic markers associated with psychosis-associated diseases such as bipolar disease or schizophrenia, the method comprising a) obtaining a first group of samples comprising genomic DNA from a plurality of bipolar or schizophrenic subjects and a second group of samples comprising genomic DNA from a plurality of control subjects; b) performing DNA methylation analysis to determine methylation differences in one or more DNA regions between the first group and second group of samples, wherein a methylation difference in a DNA region is indicative of an epigenetic marker associated with bipolar disease or schizophrenia. The invention also provides one or more epigenetic markers associated with psychosis-associated diseases such as bipolar disease or schizophrenia. |
申请公布号 |
US2014038840(A1) |
申请公布日期 |
2014.02.06 |
申请号 |
US201313958204 |
申请日期 |
2013.08.02 |
申请人 |
CENTRE FOR ADDICTION AND MENTAL HEALTH |
发明人 |
PETRONIS ARTURAS;MILL JONATHAN;FLANAGAN JAMES;WANG SUN-CHONG |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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