发明名称 |
ACUTE BLOOD-BRAIN BARRIER DISRUPTION USING ELECTRICAL ENERGY BASED THERAPY |
摘要 |
A method is provided for ablating brain tissue of a living mammal comprising: placing first and second electrodes in a brain of the living mammal; applying a plurality of electrical pulses through the first and second placed electrodes which are predetermined to: cause irreversible electroporation (IRE) of brain tissue of the mammal within a target ablation zone; and cause a temporary disruption of a blood brain barrier (BBB) within a surrounding zone that surrounds the target ablation zone to allow material in a blood vessel to be transferred to the surrounding zone through the temporarily disrupted BBB. Such methods are useful for delivering large molecule material within a blood vessel of the brain across the BBB, where the large molecule is otherwise blocked by the BBB from passing through the blood vessel into the brain. |
申请公布号 |
US2014039489(A1) |
申请公布日期 |
2014.02.06 |
申请号 |
US201314017210 |
申请日期 |
2013.09.03 |
申请人 |
VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. |
发明人 |
DAVALOS RAFAEL V.;ROSSMEISL JOHN H.;GARCIA PAULO A. |
分类号 |
A61B18/12;A61B18/14 |
主分类号 |
A61B18/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|