| 发明名称 |
Inhibitors of LRRK2 kinase activity |
| 摘要 |
<p>The present invention provides compounds having a structure according to Formula I: (I) or a salt or solvate thereof, wherein R1, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.</p> |
| 申请公布号 |
AU2012258977(A8) |
申请公布日期 |
2014.02.06 |
| 申请号 |
AU20120258977 |
申请日期 |
2012.05.21 |
| 申请人 |
ELAN PHARMACEUTICALS, INC. |
发明人 |
GAROFALO, ALBERT W.;AUBELE, DANIELLE L.;BOWERS, SIMEON;NEITZ, JEFFREY R.;ADLER, MARC;FRANZINI, MAURIZIO;PROBST, GARY;TROUNG, ANTH P.;YE, XIAOCONG |
| 分类号 |
C07D237/28;A61K31/502;A61P25/16;A61P25/28;A61P37/00;C07D401/04;C07D401/10;C07D401/12;C07D401/14;C07D403/04;C07D403/10;C07D405/04;C07D405/10;C07D405/12;C07D417/04 |
主分类号 |
C07D237/28 |
| 代理机构 |
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