发明名称 |
ANTIBODIES DIRECTED AGAINST ICOS AND USES THEREOF |
摘要 |
The present invention provides antibodies directed against ICOS or a derivative thereof which neutralize ICOS engagement on Treg by inhibiting the fixation between ICOS and ICOS-L and abrogate proliferation of Treg induced by plasmacytoid dendritic cells. The present invention further provides antibodies directed against ICOS or a derivative thereof which induce IL-10 and IFNγ production, induce CD4+ T cells proliferation, reduce Tconv proliferation, and increase the immunosuppressive function of Treg. |
申请公布号 |
EP2691419(A2) |
申请公布日期 |
2014.02.05 |
申请号 |
EP20120713670 |
申请日期 |
2012.03.29 |
申请人 |
INSERM - INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;INSTITUT JEAN PAOLI & IRENE CALMETTES;UNIVERSITE D'AIX MARSEILLE;UNIVERSITE CLAUDE BERNARD LYON I;CENTRE LEON BERARD |
发明人 |
FAGET, JULIEN;CAUX, CHRISTOPHE;MENETRIER-CAUX, CHRISTINE;NUNES, JACQUES;OLIVE, DANIEL |
分类号 |
C07K16/28;A61K39/395;A61P35/00;G01N33/569 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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