The present invention relates to the isolation, cloning and sequencing of the group of genes involved in the biosynthesis of coly-mycin by Streptomyces spp. CS40, and to the use of said genes to increase the production of coly-mycin and/or associated analogous compounds or derivatives by means of productive strains. Said compounds produced in the present invention can be used to treat several diseases, such as cancer, neuro-degenerative diseases and infectious diseases.
申请公布号
ES2397885(B1)
申请公布日期
2014.02.05
申请号
ES20110030010
申请日期
2011.01.05
申请人
UNIVERSIDAD DE OVIEDO;ENTRECHEM, S.L.
发明人
GARCIA LLORENTE, IGNACIO;MIGUEL VIOR, NATALIA;SIALER GUERRERO, CARLOS ALBERTO;GONZALEZ SABIN, JAVIER;FERNANDEZ BRANA, ALFREDO;MENDEZ FERNANDEZ, CARMEN;SALAS FERNANDEZ, JOSE ANTONIO;MORIS VARAS, FRANCISCO
