| 摘要 |
<p>The present invention provides a novel polyoxyethylene derivative having plural hydroxyl groups at a terminal end thereof, particularly a polyoxyethylene derivative having plural hydroxyl groups at a terminal end thereof, which can be effectively used in uses for modifying bio-related substances and can be industrially produced. A polyoxyethylene derivative represented by the formula (1) :
wherein a whole molecular weight of the polyoxyethylene derivative is 500 to 160, 000; n is 5 to 3650; L 1 , L 2 , and L 3 each independently represent an alkylene group, a phenylene group, an ester bond, an amide bond, an ether bond, a urethane bond, a carbonate bond, a secondary amino group, or a combination thereof; X represents a functional group capable of reacting with a bio-related substance; Y represents a hydrophilic group having plural hydroxyl groups made from a residual group of xylitol or volemitol or a residual group of polyglycerin of trimer to 31-mer; Z represents a residual group of a compound having 2 to 5 active hydrogen atoms; b and c are as follows: 1‰¤b‰¤4, 1‰¤c‰¤4, and 2‰¤b+c‰¤5; and d and e each independently are 0 or 1.</p> |
