发明名称 |
Antimicrobial compositions, methods of preparation thereof, and uses thereof |
摘要 |
A composition of matter comprises a cationic polymer comprising a polycarbonate chain fragment, the polycarbonate chain fragment comprising a repeat unit comprising a side chain moiety containing a quaternary amine group; and a non-charged polymer comprising a polyester chain segment and a poly(alkylene oxide) chain segment; wherein i) the cationic polymer and the non-charged polymer are amphiphilic and biocompatible, ii) the cationic polymer and the non-charged polymer form a mixed complex by non-covalent interactions in water, and iii) the mixed complex is a more effective antimicrobial agent against at least a Gram-negative microbe compared to the cationic polymer and the non-charged polymer alone when tested using otherwise identical conditions. |
申请公布号 |
US8642086(B2) |
申请公布日期 |
2014.02.04 |
申请号 |
US201113077005 |
申请日期 |
2011.03.31 |
申请人 |
COADY DANIEL JOSEPH;FUKUSHIMA KAZUKI;HEDRICK JAMES LUPTON;YANG YI YAN;INTERNATIONAL BUSINESS MACHINES CORPORATION;AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH |
发明人 |
COADY DANIEL JOSEPH;FUKUSHIMA KAZUKI;HEDRICK JAMES LUPTON;YANG YI YAN |
分类号 |
A61K9/00;A61K31/765 |
主分类号 |
A61K9/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|