发明名称 |
Short fatty acid tail polymyxin derivatives and uses thereof |
摘要 |
The present invention relates to a polymyxin derivative wherein the derivative has a total of three positive charges at physiological pH and wherein the terminal moiety (D) of the derivative comprises a total of 1 to 5 carbon atoms. The invention also relates to a method of treating a subject for a gram-negative bacterial infection by administering a polymyxin derivative of the invention in combination with a second antibacterial agent. Finally, the invention relates to a process for preparing such polymyxin derivatives. |
申请公布号 |
US8642535(B2) |
申请公布日期 |
2014.02.04 |
申请号 |
US201213462389 |
申请日期 |
2012.05.02 |
申请人 |
VAARA MARTTI SAKARI;VAARA TIMO ILMARI;NORTHERN ANTIBIOTICS LTD. |
发明人 |
VAARA MARTTI SAKARI;VAARA TIMO ILMARI |
分类号 |
C07K7/62;A61K38/12 |
主分类号 |
C07K7/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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