发明名称 |
Method of making solid dispersions of highly crystalline therapeutic compounds |
摘要 |
A process for preparing solid dispersions of highly crystalline compounds. The highly crystalline or thermally labile therapeutic compounds are processed in an extruder in combination with a solubilizing agent and optionally a plasticizer. The resulting extrudate features the therapeutic compound in an amorphous state. Particularly useful as the solubilizing agents are surfactants such as poloxamers. |
申请公布号 |
US8641948(B2) |
申请公布日期 |
2014.02.04 |
申请号 |
US201213423329 |
申请日期 |
2012.03.19 |
申请人 |
GHOGH INDRAJIT;SNYDER JENNIFER;TONG WEI QUIN;VIPPAGUNTA SUDHA;NOVARTIS AG |
发明人 |
GHOGH INDRAJIT;SNYDER JENNIFER;TONG WEI QUIN;VIPPAGUNTA SUDHA |
分类号 |
B29C47/00;B29C67/24 |
主分类号 |
B29C47/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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