Blood coagulation protein conjugates

摘要

598056 Discloses a modified blood coagulation protein comprising a)Factor IX (FIX) or Factor VIII (FVIII) and b) at least one polysialic acid (PSA) containing an active aminooxy group bound to said blood coagulation protein of (a); Wherein the blood coagulation protein has an oxime linkage between one or more oxidized carbohydrate moieties and the active aminooxy group on the PSA; wherein the protein has a specific activity of at least 50% relative to an unmodified blood coagulation protein.