Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof

摘要

Disclosed is a method for the preparation of a salt of isophosphoramide (or analog) of formula (E) comprising treating the neutral isophosphoramide (or analog) with a base under salt-forming conditions, wherein the salt-forming conditions comprise combining approximately equimolar amounts of tris(hydroxymethyl)aminomethane (also known as tris(hydroxymethyl)methylamine, Tris) and the neutral isophosphoramide (or analog).