| 摘要 |
1293645 3 - Alkoxy - 5 - phenyl - 1,3 - dihydro - 2H - 1,4 - benzodiazepin - 2 - ones RAVIZZA SA 26 May 1971 [2 June 1970] 26506/70 Heading C2C 3 - Alkoxy - 5 - phenyl - 1,3 - dihydro - 2H- 1,4-benzodiazepin-2-ones of the general formula wherein R is a halogen atom or nitro group and R 1 is a linear C 1-6 alkyl group, in the dextrorotatory form in the substantial absence of the levorotatory form, are prepared by treatment of a ( + )hemisuccinate of the general formula with the desired etherifying alcohol in the presence of an acid. The benzodiazepinones of the first general formula above in the levorotatory form are prepared analogously by treatment of the ( - ) hemisuccinates. Pharmaceutical compositions having sedative and anticonvulsant activity-comprise, as active ingredient, a benzodiazepinone of the first general formula above in the dextrorotatory form, in the substantial absence of the levorotatory form, together with a carrier.
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