| 摘要 |
NZ 603050 Disclosed is an insulin conjugate prepared by linking insulin with an immunoglobulin Fc region via a non-peptidyl polymer selected from the group consisting of polyethylene glycol, polypropylene glycol, copolymers of ethylene glycol and propylene glycol, polyoxyethylated polyols, polyvinyl alcohol, polysaccharides, dextran, polyvinyl ethyl ether, biodegradable polymers, lipid polymers, chitins, hyaluronic acid, and combinations thereof, in which the non-peptidyl polymer is linked to the amino terminal of beta chain of insulin. |
