| 摘要 |
IP No. 594589 The present disclosure relates to compounds of general formula (I) in which A, L, M, Q2, Q3, Q4, R1, R5, Ra, Rb, Rc, W, X, Y, Z1, Z2, Z3 are defined in the description, the salts thereof, particularly the physiologically acceptable salts thereof. The compounds are of potential utility in the treatment and/or prevention of inflammatory diseases and associated conditions, in particular, in the treatment and/or prevention of pain. The disclosure also relates to the use of such compounds as medicaments, to pharmaceutical compositions containing them, and to their preparation. Compounds of the disclosure include: 2-[5-(tert.Butylcarbonylaminomethyl)-2-chlorophenylamino]-6-chloro-N-(2,2,2-trifluorethyl)benzimidazole-5-carboxamide, 6-Chloro-2-{ 2-chloro-5-[(1-methylcyclohexylamido)methyllphenylamino} -N-cyclopentyl-1-methylbenzimidazole-5-carboxamide, tert-Butyl 5-chloro-2-{ 2-ch loro-5-[(1-methylcyclohexylamido)methyllphenylamino} -1-methyl-6-benzimidazolylcarbamate, N-{ 4-Chloro-3-[5-(N-cyclopentylsuIfamoyl)-1-methyl-2-benzimidazolylamino]benzyl} -1-methylcyclohexylamide, 2-{ 2-Chloro-5-[(2-thienylsulfonamido)methyllphenylamino} -N-cyclohexylmethyl-1-methylbenzimidazole-5-carboxamide, 4-Bromo-N-(2-{ 2-chloro-5-[(1-methylcyclopropylamido)methyl]phenylamino} -1-methyl-5-benzimidazolyl)benzamide, And 2 -{ 2-chloro-5-[(1-trifluoromethylcyclopropylamido)methyl]phenylamino} -N-cyclopropylmethyl-1-methylbenzimidazole-5-carboxamide. |
