| 摘要 |
Patent No. 599596 Disclosed is a method for identifying inputs necessary to elicit a regenerative response in a target tissue in need of regeneration, comprising (a) identifying functional elements of a healthy reference tissue or organ that is the same as the target tissue or organ; (b) identifying functional deficits or abnormalities associated with the target tissue or organ; (c) isolating the functional elements of the reference tissue or organ, individually or as controlled admixtures; (d) creating a core list of putative inputs representing a plurality of functional elements is identified in step (a) wherein said list comprises cell, biomaterial and bioactive molecule elements; (e) creating a test grid comprising all combinations of putative inputs from the core list; (f) conducting in vivo experiments in non-human mammals based on the test grid to ascertain the target tissue or organ functional response to the combinations tested; and (g) based on the results of the in vivo experiments, identifying the inputs capable of modulating a regenerative response in the target tissue or organ. |
