发明名称 Indole derivatives and methods for antiviral treatment
摘要 596144 Disclosed herein is a compound of formula (I), wherein the variables are defined in the specification, or a free acid, free base, salt, hydrate, solvate, clathrate, isotopologue, racemate, enantiomer, diastereomer, stereoisomer or polymorph form thereof; and the use of said compound in the treatment of a viral infection, wherein the viral infection is hepatitis C virus. Embodiments of the compound include the following: N-[6-(3-cyano-1-cyclobutyl-6-methoxy-1H-indol-2-yl)pyridazin-3-yl]ethanesulfonamide, and 5-fluoro-6-methyl-1-(pyridin-3-yl)-2-(5-{ [(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl} pyridin-2-yl)-1H-indole-3-carboxamide.
申请公布号 NZ596144(A) 申请公布日期 2014.01.31
申请号 NZ20100596144 申请日期 2010.04.05
申请人 PTC THERAPEUTICS INC. 发明人 HUANG SONG XIAO;MORRILL CHRISTIE;MACCOSS MALCOLM;LIU RONGGANG;KARP GARY MITCHELL;ZHANG NANJING;NJOROGE F. GEORGE;REN HONGYU;LI CHUNSHI;NOMEIR AMIN;LENNOX WILLIAM JOSEPH;TURPOFF ANTHONY A.;LIU YALEI;ZHANG XIAOYAN;ZHU JIN;KAKARLA RAMESH;SMITH SEAN W.;CHEN GUANGMING;TAKASUGI JAMES;PAGET STEVEN D.
分类号 C07D401/04;A61K31/443;A61K31/4433;A61K31/4436;A61K31/4439;A61K31/444;A61K31/506;A61P31/12;C07D401/14;C07D403/04;C07D405/14;C07D409/14;C07D413/14;C07D417/14 主分类号 C07D401/04
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