发明名称 |
APPARATUS AND METHOD OF CONTROLLING THE RATE OF NICOTINE DELIVERY |
摘要 |
<p>The present disclosure provides for an apparatus and related method for controlling the rate of nicotine delivery into systemic circulation of a subject. The method comprises transdermally administering nicotine at a topical administration site of a subject; achieving a steady state plasma concentration of nicotine in the subject; and activating a temperature modification apparatus over the topical administration site after achieving the steady state. The temperature modification apparatus can be configured to generate heat for a predetermined period of time. Further, about 5 to about 30 minutes following activation of the temperature modification apparatus, the subject's nicotine plasma concentration increases by at least about 5% over the subject's steady state nicotine plasma concentration.</p> |
申请公布号 |
WO2014015436(A1) |
申请公布日期 |
2014.01.30 |
申请号 |
WO2013CA50577 |
申请日期 |
2013.07.25 |
申请人 |
NUVO RESEARCH INC. |
发明人 |
ZHANG, JIE;HULL, WADE, A. |
分类号 |
A61K9/70;A61K31/465;A61M37/00;A61P25/34 |
主分类号 |
A61K9/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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