发明名称 Substituted tetrahydropyran spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof
摘要 <p>The present disclosure relates to a series of substituted N-phenyl-bipyrrolidine carboxamides of formula (I): wherein R1, R2, m, n and p are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, methods of preparation of substituted N-phenyl-bipyrrolidine carboxamides and intermediates therefore are disclosed.</p>
申请公布号 IL213292(A) 申请公布日期 2014.01.30
申请号 IL20110213292 申请日期 2011.05.31
申请人 SANOFI 发明人
分类号 A61K;A61P;C07D 主分类号 A61K
代理机构 代理人
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