发明名称 |
REGULATING THE INTERACTION BETWEEN TAM LIGANDS AND LIPID MEMBRANES WITH EXPOSED PHOSPHATIDYLSERINE |
摘要 |
The present disclosure provides methods for modulating the interaction between a TAM ligand and a lipid membrane containing phosphatidyl serine (PtdSer). In one example, such methods use a TAM receptor agonist having a PtdSer -containing lipid bilayer membrane with Gas6 and/or Protein S bound to the membrane to activate signaling from one or more TAM receptors and treat an autoimmune disease. In another example, methods are provided for treating a subject with a pathological condition characterized by overactivation of TAM signaling and/or reduction in Type I IFN response, such as infection by an enveloped virus, by use of agents that decrease the interaction between a TAM ligand and PtdSer. Also provided are methods for classifying a virus as susceptible to anti-TAM therapy. Methods of identifying an agent that blocks virus infectivity are also provided. |
申请公布号 |
CA2879542(A1) |
申请公布日期 |
2014.01.30 |
申请号 |
CA20132879542 |
申请日期 |
2013.07.23 |
申请人 |
SALK INSTITUTE FOR BIOLOGICAL STUDIES;XETRIOS THERAPEUTICS, INC. |
发明人 |
LEMKE, GREG E.;FRITZ, LAWRENCE C.;VOLLRATH, BENEDIKT;ROTHLIN, CARLA V. |
分类号 |
A61K39/395;A61K9/127;A61K9/16;A61P19/02;A61P37/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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