BENZENE RING-FUSED, NITROGEN-CONTAINING 5-MEMBERED HETEROCYCLIC COMPOUND OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF

摘要

[Problem] To provide a novel compound having EP1 receptor antagonist activity, or a pharmacologically acceptable salt thereof. [Solution] A benzene ring-fused, nitrogen-containing 5-membered heterocyclic compound indicated by general formula (I) or a pharmacologically acceptable salt thereof was found to have powerful EP1 receptor antagonist activity. The compound (I) or a pharmacologically acceptable salt thereof is effective as a therapeutic medication or preventative medication for lower urinary tract symptoms (LUTS), for example, and overactive bladder syndrome (OABs), etc., in particular. In addition, the compound (I) or a pharmacologically acceptable salt thereof is highly useful in the treatment, prevention, or suppression of a variety of conditions involving EP1 receptors, in addition to lower urinary tract symptoms (LUTS) (e.g., inflammatory conditions, painful conditions, osteoporosis, cancer, etc.).