发明名称 |
Screening method utilizing thalidomide-targeting factor |
摘要 |
<p>Disclosed is a means for developing a compound which has no teratogenicity while retaining a useful activity. Specifically disclosed is a method for screening for a non-teratogenic substance, which is characterized by comprising: bringing each of test substances into contact with cerebron or a fragment thereof; evaluating the bindability of the test substances to cerebron or the fragment thereof; and selecting a test substance that does not bind to cereblon or the fragment thereof or a test substance that has lower bindability to cereblon or the fragment thereof compared to that of thalidomide.</p> |
申请公布号 |
AU2010309035(B2) |
申请公布日期 |
2014.01.30 |
申请号 |
AU20100309035 |
申请日期 |
2010.10.18 |
申请人 |
TOKYO INSTITUTE OF TECHNOLOGY;FUJIMOTO PHARMACEUTICAL CORPORATION |
发明人 |
HANDA, HIROSHI;ANDO, HIDEKI;ITOH, TAKUMI;HOTTA, KENTARO |
分类号 |
G01N33/566;A01K67/027;C07K14/435;C12N15/09;G01N33/15;G01N33/50 |
主分类号 |
G01N33/566 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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