发明名称 |
GENETICALLY MODIFIED PROBIOTIC FOR THE TREATMENT OF PHENYLKETONURIA (PKU) DISEASE |
摘要 |
A GMP adapted to provide the PAL gene for the treatment of PKU when administered orally. The GMP of the present invention may include a probiotic, a PAL gene to be expressed using the probiotic. wherein the PAL gene is functionally attached to a promoter and a ribosome binding site, and may be codon-optimized for expression in a certain host organism. A method of treating the metabolic disease of PKU by oral administration and ingestion of a GMP is also provided. |
申请公布号 |
CA2880620(A1) |
申请公布日期 |
2014.01.30 |
申请号 |
CA20132880620 |
申请日期 |
2013.07.26 |
申请人 |
UNIVERSITY OF NORTH TEXAS |
发明人 |
DEMING, KATHERINE;ALLEN, MICHAEL;VON HERBING, IONE HUNT |
分类号 |
A61K35/74;A61K38/51;A61K48/00 |
主分类号 |
A61K35/74 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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