| 摘要 |
PROBLEM TO BE SOLVED: To provide a manufacturing method of a tablet that is a simple manufacturing method of a tablet containing clopidogrel sulfate which is unstable to water and easily generates tableting problem, the method being capable of hardly generating tableting problem, and maintaining the storage stability in a long period of time.SOLUTION: The method comprises the step of preliminarily mixing clopidogrel sulfate with a lubricant (except for magnesium stearate) in the absence of water, adding an additive agent, and mixing and tableting them. The lubricant is preferably a hardened oil, fatty acid ester, light anhydrous silicic acid, or hydrated silicon dioxide, etc. |
