| 摘要 |
PROBLEM TO BE SOLVED: To provide a pharmacodynamic (PD) marker inducible by interferon α (IFNα), a probe and kit that detect the PD marker, and a method employing the same.SOLUTION: A method for identifying an SLE patient as a candidate for an antibody that binds to and modulates IFNα activity. The method comprises the steps of: detecting presence or absence of an IFNα-inducible PD marker expression profile in a sample from the patient; and identifying the patient as the candidate for the antibody that binds to and modulates IFNα activity by detecting the presence of the IFNα-inducible PD marker expression profile. The IFNα-inducible PD marker expression profile comprises up-regulated expression or activity of at least one gene set selected from the group consisting of MX1, LY6E, IFI27, OAS1 IFIT1, IFI6, IFI44L, ISG15, LAMP3, OASL, RSAD2, and IFI44. |
