发明名称 ADENINE DERIVATIVES AND USE THEREOF IN THERAPY
摘要 Compounds of formula (I)wherein Ris Calkylamino, or Calkoxy; Ris a group having the structuren is an integer having a value of 1 to 6; Het is a 6-membered saturated heterocycle containing one nitrogen atom wherein Het is attached to the -(CH)- moiety at any carbon atom of the heterocycle; Ris hydrogen, Calkyl, or CcycloalkylCalkyl; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.
申请公布号 EA019204(B1) 申请公布日期 2014.01.30
申请号 EA20110000115 申请日期 2009.08.07
申请人 GLAXOSMITHKLINE LLC 发明人 BAZIN-LEE HELENE;COE DIANE, MARY;LAZARIDES LINOS;MITCHELL CHARLOTTE, JANE;SMITH STEPHEN, ALLAN;TRIVEDI NAIMISHA
分类号 A61K31/522;A61P29/00;C07D473/16;C07D473/18 主分类号 A61K31/522
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