IMMUNOGLOBULIN CONSTRUCTS COMPRISING SELECTIVE PAIRING OF THE LIGHT AND HEAVY CHAINS
摘要
<p>Disclosed herein is an isolated immunoglobulin construct comprising a first monomeric polypeptide comprising a first single chain Fv polypeptide connected to a first constant domain polypeptide; and a second monomeric polypeptide comprising a second single chain Fv polypeptide, connected to a second constant domain polypeptide; each said constant domain polypeptide comprising at least one each of a CL domain, a CH1 domain, a CH2 domain and a CH3 domain or fragments, variants or derivatives thereof; and wherein said first and second constant domain polypeptide form a Fc region.</p>
申请公布号
WO2014018572(A2)
申请公布日期
2014.01.30
申请号
WO2013US51747
申请日期
2013.07.23
申请人
ZYMEWORKS INC.
发明人
DIXIT, SURJIT, BHIMARAO;UROSEV, DUNJA;D'ANGELO, IGOR, EDMONDO, PAOLO;NG, GORDON, YIU, KON