发明名称 |
GENE-WIDE SIGNIFICANCE (GWIS) TEST: NOVEL GENE-BASED METHODS FOR THE IDENTIFICATION OF GENETIC ASSOCIATIONS HAVING MULTIPLE INDEPENDENT EFFECTS |
摘要 |
A novel set of methods for gene-based tests of association are provided. By gathering multiple independent effects into a single test, GWiS has greater power than conventional tests to identify genes with multiple causal variants. GWiS also retains power for low-frequency minor alleles that are increasingly important for personal genetics, a feature not shared by other multi-SNP tests. The methods of the present invention can be combined with conventional computing platforms to provide a new analytical tool for analyzing genes which are linked to multiple traits. |
申请公布号 |
US2014032122(A1) |
申请公布日期 |
2014.01.30 |
申请号 |
US201313953403 |
申请日期 |
2013.07.29 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
BADER JOEL;HUANG HAILIANG;ARKING DANIEL E.;CHANDA PRITAM |
分类号 |
G06F19/18 |
主分类号 |
G06F19/18 |
代理机构 |
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