发明名称 |
NUCLEIC ACIDS FOR DOWN-REGULATION OF GENE EXPRESSION |
摘要 |
Recombinant nucleic acid molecules are provided that form hair pin structures and can be used to down-regulate gene expression. For example, a nucleic acid molecule can comprise a flanking and lower stem loop sequence from a mir-16 gene; an antisense target sequence; a mir-30 loop sequence; a complement of the anti-sense target sequence; and a lower stem loop complementary to the mir-16 sequence. Methods for down regulating gene expression in a cell using such recombinant nucleic acid molecules are also provided. |
申请公布号 |
CA2879514(A1) |
申请公布日期 |
2014.01.30 |
申请号 |
CA20132879514 |
申请日期 |
2013.09.13 |
申请人 |
UNIVERSITE DE GENEVE;UNIVERSITY OF PRETORIA |
发明人 |
KRAUSE, KARL-HEINZ;MYBURGH, RENIER;SALMON, PATRICK |
分类号 |
C12N15/113;C12N15/11 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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