发明名称 |
PROCESS FOR PREPARING RACEMIC NICOTINE |
摘要 |
Provided is a process for preparing racemic nicotine from 1-methyl-3-nicotinoyl-2-pyrrolidone or a salt thereof using one-pot process. The process comprises the following steps: 1) in a reaction vessel, reacting 1-methyl-3-nicotinoyl-2-pyrrolidone or a salt thereof in the presence of a suitable solvent and a strong acid by heat; after the reaction is complete, cooling the same and adjusting the pH to 7-8 with alkali; and 2) directly adding a reductant into the above vessel, and after the reaction, purifying the product so as to obtain high purity racemic nicotine or a salt thereof. |
申请公布号 |
US2014031554(A1) |
申请公布日期 |
2014.01.30 |
申请号 |
US201213982095 |
申请日期 |
2012.01.20 |
申请人 |
TIAN GUANGHUI;WANG GUAN;KONG XIAOGUANG;ZHANG RONGXIA;CHEN WEIMING;SHEN JINGSHAN;TOPHARMAN SHANGHAI CO., LTD.;TOPHARMAN SHANDONG CO., LTD.;SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES |
发明人 |
TIAN GUANGHUI;WANG GUAN;KONG XIAOGUANG;ZHANG RONGXIA;CHEN WEIMING;SHEN JINGSHAN |
分类号 |
C07D401/04 |
主分类号 |
C07D401/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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