发明名称 |
Screening methods using G-protein coupled receptors and related compositions |
摘要 |
The present invention relates to a polypeptide, or pharmaceutically acceptable salt thereof, comprising the formula PTH(1-X)/PTHrP(Y-36). Further, the present invention refers to a polypeptide which binds the PTH receptor and has a high affinity for the R 0 form of the PTH receptor and to a polypeptide having affinity for PTH RG and a low affinity for PTH R 0 . Moreover, the present invention includes to a pharmaceutical composition comprising such polypeptide. The present invention further relates to a polypeptide or a pharmaceutical composition of the present invention for use in a method for treating a disease or condition. Moreover, the present invention refers to a nucleic acid comprising a sequence encoding a polypeptide of the present invention, a vector comprising said nucleic acid, a cell comprising said vector and a method of making a polypeptide of the present invention. Finally, the present invention further relates to a method for determining whether a candidate compound is a long-acting agonist of a G protein coupled receptor (GPCR). |
申请公布号 |
EP2650009(A3) |
申请公布日期 |
2014.01.29 |
申请号 |
EP20130001965 |
申请日期 |
2008.08.01 |
申请人 |
THE GENERAL HOSPITAL CORPORATION;CHUGAI PHARMACEUTICAL CO., LTD. |
发明人 |
GARDELLA, THOMAS J.;POTTS, JOHN T.;SHIMIZU, MASARU;ICHIKAWA, FUMIHIKO;JUEPPNER, HARALD;OKAZAKI, MAKOTO |
分类号 |
A61K38/04;A61K38/00;G01N33/50;G01N33/74 |
主分类号 |
A61K38/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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