发明名称 |
BENZOXAZEPIN COMPOUNDS SELECTIVE FOR PI3K P110 DELTA AND METHODS OF USE |
摘要 |
Benzoxazepin Formula I compounds, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological disorders, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed. |
申请公布号 |
EP2688891(A1) |
申请公布日期 |
2014.01.29 |
申请号 |
EP20120709329 |
申请日期 |
2012.03.20 |
申请人 |
F.HOFFMANN-LA ROCHE AG |
发明人 |
ELLIOTT, RICHARD;GANCIA, EMANUELA;HEALD, ROBERT;HEFFRON, TIMOTHY;SAFINA, BRIAN;SEWARD, EILEEN, M.;STABEN, STEVEN;SUTHERLIN, DANIEL, P.;WASZKOWYCZ, BOHDAN;WEI, BINQING |
分类号 |
C07D498/04;A61K31/553;A61P3/00;A61P5/00;A61P19/00;A61P25/00;A61P31/12;A61P35/00;A61P37/00;C07D498/14;C07D519/00 |
主分类号 |
C07D498/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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