发明名称 |
DERIVATIVES OF ALLOPREGNANOLONE AND OF EPIALLOPREGNANOLONE AND USES THEREOF FOR TREATING A NEUROPATHOLOGICAL CONDITION |
摘要 |
<p>The present invention relates to novel neurosteroids, especially derivatives of allopregnanolone and of epiallopregnanolone of formula (I) and the uses thereof as medicament for the treatment of neuropathologies, in particular neuropathies induced by the chemotherapy of a cancer. These molecules according to the invention have both preventative and curative effects. The neurosteroids according to the invention may also be of use in the treatment of neurodegenerative disorders, in particular for preventing neuronal cell death. They may thus be used as neuroprotectants and/or as an agent that stimulates neuronal proliferation.</p> |
申请公布号 |
EP2688902(A1) |
申请公布日期 |
2014.01.29 |
申请号 |
EP20120717373 |
申请日期 |
2012.03.23 |
申请人 |
UNIVERSITE DE STRASBOURG;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS |
发明人 |
MENSAH-NYAGAN, AYIKOE GUY;MEYER, LAURENCE;PATTE-MENSAH, CHRISTINE;TALEB, OMAR;MIESCH, MICHEL;GEOFFROY, PHILIPPE;RESSAULT, BLANDINE |
分类号 |
C07J7/00;A61K31/57;A61P25/00;A61P25/02;A61P25/04;A61P25/28;C07J13/00;C07J17/00 |
主分类号 |
C07J7/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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