发明名称 |
Molecular scaffolds for HIV-1 epitopes |
摘要 |
Methods and compositions are provided for the use of an envelope polypeptide or a functional variant thereof from a lentivirus that is not HIV-1 as a molecular scaffold for HIV-1 epitopes. The HIV-1 epitopes can be recognized by HIV-1 binding antibodies, HIV-1 neutralizing antibodies and/or CD4-induced antibodies. Thus, methods are provided for detecting HIV-1 binding antibodies in a subject infected with HTV-1. Further provided are methods to determine an epitope for an HIV-1 binding antibody; methods to assay for an HIV-1 binding antibody; methods to identify a soluble CD4 mimic; methods to neutralize an non-HIV-1 virus; diagnostic assays to monitor HIV disease in a subject or to monitor the subject's response to immunization by a HIV vaccine; and methods to alter the neutralization potential of an HIV-1 derived CD4-induced antibody. Chimeric polypeptides, chimeric polynucleotides, kits, cells and viruses are also provided. |
申请公布号 |
US8637234(B2) |
申请公布日期 |
2014.01.28 |
申请号 |
US20050578761 |
申请日期 |
2005.04.08 |
申请人 |
SHAW GEORGE M.;ROBINSON JAMES E.;BIBOLLET-RUCHE FREDERIC;DECKER JULIE M.;HAHN BEATRICE H.;KWONG PETER D.;UAB RESEARCH FOUNDATION;THE ADMINISTRATORS OF TULANE EDUCATIONAL FUND;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
SHAW GEORGE M.;ROBINSON JAMES E.;BIBOLLET-RUCHE FREDERIC;DECKER JULIE M.;HAHN BEATRICE H.;KWONG PETER D. |
分类号 |
C12Q1/70;A61K39/00;A61K39/12;A61K39/21;A61K39/38;C07K16/00;C07K16/10;C07K16/28;G01N33/569 |
主分类号 |
C12Q1/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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