发明名称 |
SYSTEMS AND METHODS FOR MANUFACTURING LIPOSOMES |
摘要 |
<p>The present invention provides apparatus and processes for producing liposomes. By providing a buffer solution in a first reservoir, and a lipid solution in a second reservoir, continuously diluting the lipid solution with the buffer solution in a mixing chamber produces a liposome. A therapeutic agent, such as a nucleic acid, is included in one of the buffer solution or the lipid solution. Upon mixing a liposome encapsulating the therapeutic product is substantially instantaneously formed. Thereafter the liposome solution formed is immediately diluted with buffer solution to enhance homogeneity and maintain small particle size.</p> |
申请公布号 |
CA2616877(C) |
申请公布日期 |
2014.01.28 |
申请号 |
CA20062616877 |
申请日期 |
2006.07.27 |
申请人 |
PROTIVA BIOTHERAPEUTICS, INC. |
发明人 |
JEFFS, LLOYD B.;LAM, KIEU;MACLACHLAN, IAN;YAWORSKI, EDWARD |
分类号 |
A61K9/127;A61K31/7088;A61K38/00;A61K38/43;A61K39/00;A61K47/44;A61K48/00 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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