发明名称 |
Antagonist anti-CD40 monoclonal antibodies and methods for their use |
摘要 |
Compositions and methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40-expressing cells, such as B cells. |
申请公布号 |
US8637032(B2) |
申请公布日期 |
2014.01.28 |
申请号 |
US201213612070 |
申请日期 |
2012.09.12 |
申请人 |
LONG LI;YABANNAVAR ASHA;ZAROR ISABEL;LEE SANG HOON;HURST DEBORAH;NOVARTIS VACCINES AND DIAGNOSTICS, INC. |
发明人 |
LONG LI;LUQMAN MOHAMMAD;YABANNAVAR ASHA;ZAROR ISABEL;LEE SANG HOON;HURST DEBORAH |
分类号 |
A61K39/395;C07K16/28 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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