发明名称 |
Determination of von Willebrand Factor cleavage by ADAMTS13 |
摘要 |
Novel methods are described for measuring the rate of ADAMTS13-mediated cleavage of von Willebrand Factor (VWF) multimers. Through the use of the reagent, ristocetin, the method can advantageously be performed in the absence of an applied shear stress or added denaturing agent. Also described are methods for diagnosing ADAMTS13-associated disorders and methods for providing improved treatment of those disorders by evaluating the efficacy of the treatment using the methods as described. |
申请公布号 |
US8637268(B2) |
申请公布日期 |
2014.01.28 |
申请号 |
US201113289474 |
申请日期 |
2011.11.04 |
申请人 |
CHEN JUNMEI;CHUNG DOMINIC W.;LOPEZ JOSE ARON;PUGET SOUND BLOOD CENTER |
发明人 |
CHEN JUNMEI;CHUNG DOMINIC W.;LOPEZ JOSE ARON |
分类号 |
C12Q1/56 |
主分类号 |
C12Q1/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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