发明名称 |
Adjuvant incorporation in immunonanotherapeutics |
摘要 |
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof. |
申请公布号 |
US8637028(B2) |
申请公布日期 |
2014.01.28 |
申请号 |
US200913123888 |
申请日期 |
2009.10.09 |
申请人 |
ALEXIS FRANK;IANNACONE MATTEO;SHI JINJUN;BASTO PAMELA;MOSEMAN ELLIOTT ASHLEY;VON ANDRIAN ULRICH;LANGER ROBERT S.;FAROKHZAD OMID C.;TONTI ELENA;PRESIDENT AND FELLOWS OF HARVARD COLLEGE;MASSACHUSETTS INSTITUTE OF TECHNOLOGY;THE BRIGHAM AND WOMEN'S HOSPITAL |
发明人 |
ALEXIS FRANK;IANNACONE MATTEO;SHI JINJUN;BASTO PAMELA;MOSEMAN ELLIOTT ASHLEY;VON ANDRIAN ULRICH;LANGER ROBERT S.;FAROKHZAD OMID C.;TONTI ELENA |
分类号 |
A61K39/395;A61K39/40;A61K49/04 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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