发明名称 |
PROCESS FOR PRODUCING THIOPHENE COMPOUND AND INTERMEDIATES |
摘要 |
Disclosed is a novel process for producing a 2-aryl-3-hydroxy-4-substituted-carbonylthiophene compound, which is a compound useful as an intermediate for the production of a pharmaceutical agent or an agricultural agent or an intermediate for the production of the 2-aryl-3-hydroxy-4-substituted-carbonylthiophene compound. A 2-aryl-3-hydroxy-4-substituted-carbonylthiophene compound (7) can be produced by: reacting a 2-arylacetic acid ester compound represented by formula (1) [wherein Rrepresents an aryl group or the like; Rrepresents a Calkyl group or the like; and X represents a leaving group] with a thioacetic acid compound to produce a thioacetyl compound (3); reacting the thioacetyl compound (3) with a vinyl ketone compound to produce a γ-ketosulfide compound (5); cyclizing the γ-ketosulfide compound (5) under basic conditions to produce a dihydrothiophene compound (6); oxidizing the dihydrothiophene compound (6) with an oxidizing agent to produce the 2-aryl-3-hydroxy-4-substituted-carbonylthiophene compound (7). |
申请公布号 |
UA104286(C2) |
申请公布日期 |
2014.01.27 |
申请号 |
UA20100011336 |
申请日期 |
2009.02.27 |
申请人 |
NISSAN CHEMICAL INDUSTRIES, LTD. |
发明人 |
YANAGIHARA, KAZUFUMI;OWADA, SHINGO;MIYAJI, KATSUAKI |
分类号 |
C07D333/32;C07C319/20;C07C323/56 |
主分类号 |
C07D333/32 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|