| 摘要 |
FIELD: medicine.SUBSTANCE: invention represents a pharmaceutical composition for treating HIV infection as a solid dosage form containing at least one HIV protease inhibitor in a therapeutically effective amount specified in a group of nelfinavir, sacvinavir, tipranavir, darunavir, indinavir, ritonavir, lopinavir, palinavir or fosamprenavir, and pharmaceutically acceptable additives, differing by the fact that the pharmaceutically acceptable additives are presented by at least one water-soluble polymer in the amount of 0.4 to 49 wt % of the weight of the ready dosage form, one water-insoluble polymer in the amount of 0.39 to 28 wt % of the weight of the ready dosage form, surfactants, excipients to the weight of 100% of the ready dosage form, as well as a method of treating HIV infection.EFFECT: composition possesses the improved technological properties and bioavailability as compared to a prototype drug.13 cl, 7 ex, 1 dwg |
