发明名称 |
PURIFIED CARDIOGENIN ISOMER AND RELATED METHODS |
摘要 |
A cardiogenin major isomer is obtained from a methanol extract of Geum japonicum and separated from its minor isomer. The separation of the two isomers can be achieved by chiral phase chromatography, e.g., using a Chiralpak® IC(TM) column. The purity of the isolated cardiogenin major isomer can be further increased by crystallization, yielding isolated cardiogenin major isomer having HPLC purity as high as 98.97% (a/a) at 210 nm and a potency of 95.50%) (w/w). |
申请公布号 |
KR20140010936(A) |
申请公布日期 |
2014.01.27 |
申请号 |
KR20137017891 |
申请日期 |
2011.12.21 |
申请人 |
HUYA BIOSCIENCE INTERNATIONAL LLC |
发明人 |
KYAS ANDREAS;FREUND ERNST;SCHLOERKE OLIVER;PATERNITI JAMES R.;ELLIOTT GARY;LILL JORG;ROGALL LARS;MENIA DARIO |
分类号 |
C07H15/24;A61K31/70;A61K36/73;C07J19/00 |
主分类号 |
C07H15/24 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|