Analogos de glucagon que presentan actividad potente en receptor de gip; dimero o multidimero; conjugado; composicion farmaceutica que los comprende; y sus usos en tratar diabetes u obesidad.

摘要

Provided herein are glucagon analogs which exhibit potent activity at the GIP receptor, and, as such are contemplated for use in treating diabetes and obesity. In exemplary embodiments, the glucagon analog of the present disclosures exhibit an EC50 at the GIP receptor which is within the nanomolar or picomolar range.