发明名称 METHOD FOR PRODUCING DIAMINE DERIVATIVE
摘要 The present invention provides a method for producing a compound represented by formula (A), the method comprising the steps of: (a) mixing a compound represented by formula (B) with p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate at less than 1 molar equivalent with respect to the compound represented by formula (B) in a solvent under heating; (b) adding additional p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate to the mixed solution under cooling, wherein the additional p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate is added in such an amount that the total molar equivalent thereof with the p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate of step (a) is 1 molar equivalent or more with respect to the compound represented by formula (B) of step (a); and (c) subsequently allowing the mixed solution to crystallize to obtain the compound represented by formula (A).
申请公布号 HK1162467(A1) 申请公布日期 2014.01.24
申请号 HK20120102504 申请日期 2012.03.13
申请人 DAIICHI SANKYO COMPANY LIMITED 发明人 KOYAMA, TAKEO
分类号 C07D;A61K;A61P 主分类号 C07D
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