| 发明名称 |
SPIRO-[1,3]-OXAZINES AND SPIRO-[1,4]-OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS. |
| 摘要 |
<p>The present invention provides spiro-[l,3]-oxazines and spiro-[l,4]-oxazepines of formula (I) having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.</p> |
| 申请公布号 |
MX2013013910(A) |
申请公布日期 |
2014.01.24 |
| 申请号 |
MX20130013910 |
申请日期 |
2012.05.24 |
| 申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
ROBERT NARQUIZIAN;WOLFGANG WOSTL;EMMANUEL PINARD |
| 分类号 |
C07D498/10;A61K31/537;A61P25/28 |
主分类号 |
C07D498/10 |
| 代理机构 |
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