| 摘要 |
PURPOSE: A diterpene furanoids compound inhibiting a protein tyrosine dephosphorylation enzyme 1B, and the use thereof are provided to have an excellent effect of medical treatment on insulin-independent type-2 diabetes. CONSTITUTION: A Huea coralligera extract has an activity inhibition of a protein tyrosine dephosphorylation enzyme 1B(PTP1B). The Huea coralligera extract is extracted with a solvent selected from the group of water, lower alcohol with 1-4 carbons, and a mixture thereof. The diterpene furanoids compound is represented by chemical formula 1-4. A separation method of a Hueafuranoids compound is represented by the chemical formula 1 or the chemical formula 2. A pharmaceutical composition for the treatment of type-2 diabetes contains the Huea coralligera extract as an active ingredient. |
