发明名称 |
METHODS, KITS AND COMPOSITIONS FOR PROVIDING A CLINICAL ASSESSMENT OF PROSTATE CANCER |
摘要 |
The present invention relates to prostate cancer signatures which are useful for providing a clinical assessment of prostate cancer from a biological sample of a subject. By performing initial gene expression studies on urine samples from prostate cancer and non-prostate cancer subjects, and using the PCA3/PSA prostate cancer test as a performance benchmark, the present inventors have surprisingly discovered multiple signatures that are informative in urine-based prostate cancer tests, as well as in tissue-based tests. The signatures relate to combinations of at least two prostate cancer markers whose expression pattern in urine has been validated as being associated (either positively or negatively) with a clinical assessment of prostate cancer. The prostate cancer markers can be used in conjunction with bioinformatics approaches to generate a prostate cancer score, which correlates with a clinical assessment of prostate cancer. Methods, kits and compositions relating to the aforementioned signatures are also described. |
申请公布号 |
WO2014012176(A1) |
申请公布日期 |
2014.01.23 |
申请号 |
WO2013CA50452 |
申请日期 |
2013.06.14 |
申请人 |
DIAGNOCURE INC. |
发明人 |
HAINCE, JEAN-FRANCOIS;BEAUDRY, GUILLAUME;FRADET, YVES;PAQUET, ERIC |
分类号 |
C12Q1/68;C40B30/00;C40B30/04;G01N33/48;G01N33/68;G06F19/12 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|