CHIRAL Alpha-METHYLENE-Beta-LACTAM COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF

摘要

Disclosed are a chiral alpha-methylene-beta-lactam compound and a preparation method and an application thereof. An asymmetric allyl amination reaction of catalyzing a class of Morita-Baylis-Hillman adducts by using a complex formed by a chiral phosphine ligand and metal palladium as a catalyst is a key step, and a key midbody chiral alpha-methylene-beta-substituted amino carboxylic acid derivative can be prepared with high activity and high selectivity, and a chiral alpha-methylene-beta-lactam compound can be prepared through a cyclization step. This class of compounds has antitumor activity.