发明名称 |
METHODS AND COMPOSITIONS FOR TREATMENT OF DISEASE OR INJURY OF THE NERVOUS SYSTEM |
摘要 |
Methods for producing new neurons in the brain in vivo are provided according to aspects of the present invention which include introducing NeuroD1 into a glial cell, particularly into a reactive astrocyte or NG2 cell, thereby "converting" the reactive glial cell to a neuron. Methods of producing a neuronal phenotype in a glial cell are provided according to aspects of the present invention which include expressing exogenous NeuroD1 in the glial cell, wherein expressing exogenous NeuroD1 includes delivering an expression vector, such as a viral expression vector, including a nucleic acid encoding the exogenous NeuroD1 to the glial cell. |
申请公布号 |
US2014024599(A1) |
申请公布日期 |
2014.01.23 |
申请号 |
US201313946419 |
申请日期 |
2013.07.19 |
申请人 |
CHEN GONG;GUO ZIYUAN;WU ZHENG;THE PENN STATE RESEARCH FOUNDATION |
发明人 |
CHEN GONG;GUO ZIYUAN;WU ZHENG |
分类号 |
A61K48/00;A61K38/17;C12N15/86 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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