Ethynylindole compounds

摘要

As a compound having a potent oral activity and a long-lasting cysLT1 /cysLT 2 receptor antagonistic activity, 5 the compound of the formula (I): which exhibits potent antagonistic activity against the cysLTi/cysLT2 receptor, and have long-lasting effects even in case of oral administration, and therefore is useful 10 as an oral agent for preventing and/or treating a variety of diseases, for example, respiratory disease (for. example, asthma (bronchial asthma, etc.), chronic obstructive pulmonary disease (COPD), pulmonary emphysema, chronic bronchitis, pneumonia (interstitial 15 pneumonia, etc.), severe acute respiratory syndrome (SARS), acute respiratory distress syndrome (ARDS), apnea syndrome, allergic rhinitis, sinusitis (acute sinusitis, chronic sinusitis, etc.), pulmonary fibrosis, coughing (chronic coughing, etc.), and the like) was developed.