| 摘要 |
Disclosed herein are stable amorphous coprecipitates of linezolid and a pharmaceutically acceptable excipient, methods for the preparation, pharmaceutical compositions, and method of treating thereof. The amorphous coprecipitates of linezolid disclosed herein are consistently reproducible, do not have the tendency to convert to crystalline forms, and are found to be more stable. The amorphou coprecipitates of linezolid disclosed herein exhibit properties making them suitable for formulating linezolid. More particularly, disclosed herein are amorphous coprecipitates of linezolid with improved physiochemical characteristics which help in the effective bioavailability of linezolid. Such pharmaceutical compositions may be administered easily to a mammalian patient in a dosage form, e.g., liquid, powder, elixir, injectable solution, with a high rate of bioavailability. |
