发明名称 |
PHARMACEUTICAL COMPOSITIONS OF (R)-1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL)-N-(1-(2,3-DIHYDROXYPROPYL)-6-FLUORO-2-(1-HYDROXY-2-METHYLPROPAN-2-YL)-1H-INDOL-5-YL) CYCLOPROPANECARBOXAMIDE AND ADMINISTRATION THEREOF |
摘要 |
<p>A pharmaceutical composition comprising Compound 1, (R)- 1 -(2,2- difluorobenzo[d] [ 1,3]dioxol-5-yl)-N-( 1 -(2,3-dihydroxypropyl)-6-fluoro-2-( 1 -hydroxy-2- methylpropan-2-yl)- l H-indol-5-yl)cyclopropanecarboxamide, and at least one excipient selected from : a filler, a disintegrant, a surfactant, a glidant and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis. Methods for treating a patient in need thereof include administering the pharmaceutical composition of Compound 1 are also disclosed.</p> |
申请公布号 |
CA2878057(A1) |
申请公布日期 |
2014.01.23 |
申请号 |
CA20132878057 |
申请日期 |
2013.07.15 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
ALARGOVA, ROSSITZA GUEORGUIEVA;DUNBAR, CRAIG ANTONY;KADIYALA, IRINA NIKOLAEVNA |
分类号 |
A61K9/20;A61K31/404;A61K31/47;A61K45/06;A61P43/00 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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